Atorvastatin Calcium CAS NO.134523-03-8

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    2020-01-14 01:31

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​Hangzhou Jeci Biochem Technology Co .,Ltd.

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Product details


Atorvastatin calcium Basic information
















Product Name:




Atorvastatin calcium




Synonyms:




Atorvastatin Calcium Anhydrous;Calcium of atorvastatin;Atorvastatin ;Atorvastatin aMorphous;atorvastatine calciuM salt;(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid CalciuM Salt;Atorvastatin HeMicalciuM;Sortis




CAS:




134523-03-8




MF:




C66H68CaF2N4O10




MW:




1155.36




EINECS:




200-659-6






Atorvastatin calcium Chemical Properties












Melting point




176-178°C




storage temp.




Store at +4°C




solubility




DMSO: ≥10mg/mL




form




white powder






Atorvastatin calcium Usage And Synthesis










Mode of action




Atorvastatin takes effect through selectively and competitively inhibiting the hepatic enzyme HMG-CoA reductase, which is responsible for converting HMG-CoA to mevalonate in the cholesterol biosynthesis pathway. This results in a subsequent decrease in hepatic cholesterol levels. Decreased hepatic cholesterol levels stimulates upregulation of hepatic LDL-C receptors which increases hepatic uptake of LDL-C and reduces serum LDL-C concentrations.




Chemical Properties




White Crystalline Powder




Uses




The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease.







Atorvastatin calcium Specification

































Character




A white or almost white?crystalline powder




Identification




A: IR.

B: CALCIUM




water




3.5~5.5




Ca %




3.0~3.6




Particle size




D90≤10 µm




Heavy Metals(ppm)




≤20




Impurity

(HPLC)




Impurity E




≤0.3%




Impurity A




≤0.3%




Impurity?B




≤0.3%




Impurity C




≤0.3%




Impurity D




≤0.1%




Other individual unknown Impurity %




≤0.1%




Total impurity




≤1.0%




Assay %




98.0-102.0


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